Instradent® Membrane

Instradent® Collagen Membrane (type I) is a porous non-chemical cross-linkingporcine-derived (dermis) fibrous membrane designed to achieve predictable guided bone regeneration and tissue regeneration.

Processing assures biocompatibility

Instradent® Collagen Membrane is meticulously manufactured from highly purified native collagen, ideal choice for the excellent biocompatibility and capacity to enhance wound healing process. The cross-linking has been achieved without chemicals (such as formaldehyde and glutaraldehyde) to avoid any adversely influences on surrounding tissues or leave of cytotoxic residue during the process.12, 13


The Instradent® Collagen Membrane has a multi-layer fibrous structure designed for acting as a cell occlusive barrier which protects the healing site. The porous surface is designed to helps vascularization enhancing the soft and hard tissue healing. Additionally, its high tear resistance
preserves undisturbed the bone regeneration site.

The Instradent® Collagen Membrane shows in a randomized clinical trial or in a preclinical study its successful outcomes in Guided Tissue Regeneration (GTR) or in Guided Bone Regeneration (GBR) improving key clinical parameters.

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1. A study on the safety and efficacy of bovine bone-derived bone graft material (OCS-B). J Korean Acad Periodontol. 2005 Jun;35(2):335-343.

2. Evaluation on the bone regenerative capacity of deproteinized bovine bone-derived bone graft material (OCS-B). The Journal of the Korean Dental Association. Vol.44 No.6, 2006.6, 359-366.

3. Effect of Heat-Treatment. Temperature on the Osteoconductivity of the Apatite Derived from Bovine Bone, Key Engineering Materials Vols. 309-311 (2006) pp 41-44

4. Bone reaction to bovine hydroxyapatite grafted in the mandibular defects of beagle dogs. J Korean Acad Periodontol. 2006;36:39-49.

5. Maxillary sinus floor augmentation using deproteinized bovine bone-derived bone graft material (OCB-B®). Clinical and histologic findings in human. The Journal of the Korean Dental Association. 2007; 45(8): 491-499.

6. Periodontal Repair on Intrabony Defects treated with Anorganic Bovine-derived XenoGraft. J Korean Acad Periodontol. 2007; 37(3): 489-496.

7. The comparative study - the regenerative effect depends on size of bone graft material in bone loss site around dental implant. J Korean Acad Periodontol. 2008;38:493-502.

8. A comparative analysis of basic characteristic sof several deproteinized bovine bone substitutes. J Korean Acad Periodontol. 2009;39:149-156.

9. A radiographical study on the changes in height of grafting materials after sinus lift: a comparison between two types of xenogenic materials, J Periodontal Implant Sci 2010;40:25-32

10. Comparative study of two collagen membranes for guided tissue regeneration therapy in periodontal intrabony defects: a randomized clinical trial; Young-Mi Chung, Jue-Yeon Lee, Seong-Nyum Jeong; J Periodontal Implant Sci 2014; 44:194-200

11. Biological effects of a porcine-derived collagen membrane on intrabony defects; Chang-Kyun Lee, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, In-Chul Rhyu, Young Ku, Chong-Pyoung Chung1, Yoon-Jeong Park, Jue-Yeon Lee; J Periodontal Implant Sci 2010;40:232-238

12. Speer DP, Chvapil M, Eskelson CD, Ulreich J. Biological effects of residual glutaraldehyde in glutaraldehyde-tanned collagen biomaterials. J Biomed Mater Res 1980;14:753-64.

13. Locci P, Calvitti M, Belcastro S, Pugliese M, Guerra M, Marinucci L, et al. Phenotype expression of gingival fibroblasts cultured on membranes used in guided tissue regeneration.J Periodontol 1997;68:857-63.

14. Data on files