A superfície SLActive® em pacientes que receberam tratamentos de radioterapia.

Previsibilidade que ultrapassa as expectativas

Um dos grupos mais difíceis de pacientes para o tratamento com implante inclui pacientes que foram submetidos a uma combinação de cirurgia oncológica, quimioterapia e radioterapia. A qualidade óssea destes pacientes foi gravemente comprometida. 

Saiba porquê

Desempenho da superfície SLActive® em pacientes que receberam tratamentos de radioterapia

Acompanhamento a 1 anos3

1 paciente excluído do estudo devido a recidiva do tumor. O gráfico baseia-se em 19 pacientes com 97 implantes.

Acompanhamento a 5 anos13,14

Excluindo outros 4 pacientes falecidos com cancro. O gráfico baseia-se assim em 15 pacientes com 79 implantes.

Ensaio clínico aleatorizado:3
102 implantes, 20 pacientes
Radioterapia e quimioterapia pós-cirúrgica para carcinoma oral

Acompanhamento a 5 anos: publicação mais recente

O que dizem os médicos dentistas

Atualização da Dental Tribune International

Assista a uma entrevista com o Prof. Nelson, para ficar a saber mais sobre o estudo e os desafios da reabilitação protética de pacientes que receberam tratamentos de radioterapia. Descubra como os implantes SLActive® melhoraram a qualidade de vida destes pacientes.

Ver entrevista
Descarregar descrição geral do estudo

Desempenho irrepreensível.

Mesmo em pacientes diabéticos.

Os pacientes com diabetes apresentam uma capacidade de cicatrização reduzida15,16 o que coloca os implantes dentários em risco. Mais informações >

A nível mundial, 1 em 6 adultos com idade igual ou superior a 60 anos  tem diabetes.17 Mais informações >

Devido à prevalência da diabetes tipo 2 em constante crescimento, como podem os médicos dentistas lidar com este risco, particularmente em pacientes idosos?

  • Evidências clínicas crescentes do desempenho altamente previsível da superfície slactive® em pacientes diabéticos. 
  • Um novo estudo clínico19 que comparou o desempenho da superfície SLActive® em pacientes com e sem diabetes, demonstrou o desempenho impecável dos implantes SLActive®.
  • Taxa de sucesso de 100 % nos implantes no grupo diabético após 2 anos
  • Alterações ósseas semelhantes às registadas em indivíduos saudáveis
  • Apesar dos níveis inferiores de qualidade óssea, todos os implantes deste estudo demonstraram uma boa estabilidade primária.

Desempenho no grupo de pacientes diabéticos19

Estudo clínico prospetivo com controlo de casos (15 indivíduos diabéticos e 14 não-diabéticos)

Taxa de sucesso de 100% nos implantes no grupo diabético após 2 anos

Alterações ósseas semelhantes às registadas em indivíduos saudáveis

Apesar dos níveis inferiores de qualidade óssea, todos os implantes deste estudo demonstraram uma boa estabilidade primária.

Principais investigadores do estudo

O que dizem os médicos dentistas

Descarregar descrição geral do estudo

A colocação de implantes em fumadores é frequentemente associada a elevadas taxas de insucesso, risco de infeções pós-operatórias e perda óssea marginal.29

SLActive® – elevada previsibilidade em fumadores

  • Um estudo clínico recente comparando o desempenho da SLActive® em grupos de pacientes fumadores e não fumadores reportou excelentes resultados com a SLActive®:
  • 96 pacientes, 130 implantes SLActive®, acompanhamento a 5 anos, taxa de sobrevivência de 100%
Publicação mais recente

Desempenho no grupo de pacientes fumadores30

Estudo clínico prospetivo com controlo de casos (47 fumadores e 49 não fumadores)

Perguntas? Contacte-nos.

Acordo de utilização de dados*

Leia a nossa política de privacidade.

Queira digitar de novo o código anterior

Referências

* Critérios de sucesso segundo Buser D. et al. Long-term stability of osseointegrated implants in augmented bone: A 5-year prospective study in partially edentulous patients. Int J Periodont Restor Dent. 2002; 22: 108–17.
** Ajustada, excluindo os pacientes falecidos por causas oncológicas.

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5 Verdonck, H.W.D., Meijer, G.J., Laurin, T., Nieman, F.H.M., Stoll, C., Riediger, D., Stoelinga, P.J.W. and de Baat, C. (2007) Assessment of Vascularity in Irradiated and Non-Irradiated Maxillary and Mandibular Alveolar Minipig Bone Using Laser Doppler Flowmetry. International Journal of Oral Maxillofacial Implants, 22, 774-778.
6 Hu, W.W., Ward, B.B., Wang, Z. and Krebsbach, P.H. (2010) Bone Regeneration in Defects Compromised by Radiotherapy. Journal of Dental Research, 89, 77-81. http://dx.doi.org/10.1177/0022034509352151.
7 Wang, R., Pillai, K. and Jones, P.K. (1998) Dosimetric Measurements of Scatter Radiation from Dental Implants in Stimulated Head and Neck Radiotherapy. International Journal of Oral Maxillofacial Implants, 13, 197-203.
8 Grotz, K.A., Al-Nawas, B., Piepkorn, B., Reichert, T.E., Duschner, H. and Wagner, W.(1999) Micromorphological Findings in Jaw Bone after Radiotherapy. Mund-, Kiefer- und Gesichtschirurgie, 3, 140-145.
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14 C. NACK, J.-D. RAGUSE, A. STRICKER , K. NELSON & S. NAHLES. Rehabilitation of irradiated patients with chemically modified and conventional SLA implants: five-year follow-up. Journal of Oral Rehabilitation 2015 42; 57—64.
15 Devlin H, Garland H, Sloan P. Healing of tooth extraction sockets in experimental diabetes mellitus. J. of Oral Maxillofac. Surg. 1996; 54:1087-1091
16 Wang F1, Song YL, Li DH, Li CX, Wang Y, Zhang N, Wang BG. Type 2 diabetes mellitus impairs bone healing of dental implants in GK rats. Diabetes Res Clin Pract. 2010; 88:e7-9.
17 IDF Diabetes Atlas, 7th Edition, 2015 http://www.diabetesatlas.org/.
18 US Centers for Disease Control and Prevention. Diabetes 2014 report card. Available from: www.cdc.gov/diabetes/library/reports/congress.html. Accessed September 2015.
19 Cabrera-Domínguez J, Castellanos-Cosano L, Torres-Lagares D, Machuca-Portillo G. A Prospective Case-Control Clinical Study of Titanium-Zirconium Alloy Implants with a Hydrophilic Surface in Patients with Type 2 Diabetes Mellitus. Int J Oral Maxillofac Implants. 2017 Sep/Oct;32(5):1135-1144. doi: 10.11607/jomi.5577; Cabrera-Domínguez J. A prospective, two-year clinical trial of titanium-zirconium alloy implants (Roxolid® Straumann®) with hydrophilic surface (SLActive®) in patients with Type 2 Diabetes Mellitus. presented during 26th Annual Scientific Meeting of the European Association of Osseointegration – 5-7 Oct 2017, Madrid, Spain.
20 Hotchkiss KM, Ayad NB, Hyzy SL, Boyan BD, Olivares-Navarrete R. Dental implant surface chemistry and energy alter macrophage activation in vitro. Clin. Oral Impl. Res. 00, 2016, 1–10. doi: 10.1111/clr.12814.
21 Lee R, Hamlet SM, Ivanovski S. The influence of titanium surface characteristics on macrophage phenotype polarization during osseous healing in type I diabetic rats: A pilot study. Clin Oral Impl Res (accepted 4/8/2016).
22 El Chaar E, Zhang L, Zhou Y, et al. Osseointegration of Superhydrophilic Implants Placed in Defect Grafted Bones. International Journal of Oral & Maxillofacial Implants . Mar/Apr2019, Vol. 34 Issue 2, p443-450
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24 EMPA (2017) Report additional experiments: Impact of RXD SLA, RXD SLAnano, RXD SLActive, and RXD pmod SLA surfaces on protein adsorption, blood coagulation, and osteogenic differentiation of HBCs. Final report: Impact of RXD SLA, RXD SLAnano, RXD SLActive, and RXD pmod SLA surfaces on protein adsorption, blood coagulation, and osteogenic differentiation of HBCs. EMPA, Swiss Federal Laboratories for Materials Science and Technology (data on file).
25Stavropoulos A et al. Greater Osseointegration Potential with Nanostructured Surfaces on TiZr: Accelerated vs. Real-Time Ageing. Materials (Basel). 2021 Mar 29;14(7):1678.
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29 Chrcanovic BR, Albrektsson T, Wennerberg A Smoking and dental implants: A systematic review and meta-analysis. J Dent. 2015 May;43(5):487-98
30 Alsahhap A et al. Survival of Titanium-Zirconium and Titanium Dental Implants in Cigarette-smokers and Never-smokers: A 5-Year Follow-up. Chin J Dent Res. 2019;22(4):265-272
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