Straumann Emdogain

STRAUMANN® EMDOGAIN®

THREE DECADES TRANSFORMING SMILES

For 30 years the world has changed but regeneration has always had one name: Emdogain®

Setting the gold standard in periodontal regeneration since 1995, emdogain has been at the forefront of periodontal regeneration, shaping the future of dentistry and transforming patient care.

Inspired by nature and powered by science, this unique gel harnesses the body’s natural healing process to restore both hard and soft tissues.

Emdogain Story

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EMDOGAIN STORY

Straumann® Emdogain® is a mix of enamel matrix proteins that, when applied to a clean tooth root surface, form an extracellular matrix that stimulates cells and processes that are fundamental for periodontal regeneration¹. Numerous scientific studies provide clinical evidence of the application of Straumann® Emdogain® in different indications such as intrabony defects due to moderate or severe periodontitis and gingival recession defects, designed to be used as an adjunct to surgical periodontal procedures.

Straumann Emdogain supports the predictable regeneration of the lost periodontal hard and soft tissue caused by periodontitis, helping to save and preserve the tooth.

Before treatment with Straumann® Emdogain®.
Courtesy of Prof. Carlos Nemcovsky

Before treatment with Straumann® Emdogain®.
Courtesy of Prof. Giovanni Zucchelli

20 years after treatment with Straumann® Emdogain®.
Courtesy of Prof. Carlos Nemcovsky

8 months after treatment with Straumann® Emdogain®.
Courtesy of Prof. Giovanni Zucchelli

EMDOGAIN STORY

Straumann® Emdogain® is a mix of enamel matrix proteins that, when applied to a clean tooth root surface, form an extracellular matrix that stimulates cells and processes that are fundamental for periodontal regeneration¹. Numerous scientific studies provide clinical evidence of the application of Straumann® Emdogain® in different indications such as intrabony defects due to moderate or severe periodontitis and gingival recession defects, designed to be used as an adjunct to surgical periodontal procedures.

Straumann Emdogain supports the predictable regeneration of the lost periodontal hard and soft tissue caused by periodontitis, helping to save and preserve the tooth.

Before treatment with Straumann® Emdogain®.
Courtesy of Prof. Carlos Nemcovsky

20 years after treatment with Straumann® Emdogain®.
Courtesy of Prof. Carlos Nemcovsky

Before treatment with Straumann® Emdogain®.
Courtesy of Prof. Giovanni Zucchelli

8 months after treatment with Straumann® Emdogain®.
Courtesy of Prof. Giovanni Zucchelli

30 years Emdogain®

Emdogain - 30 years in the market

1,700 scientific publications (>600 clinical)²

>3 million patients treated globally³

Extremely well tolerated⁴

Stable results documented over 10 years in 2 indications^5,10,11

Long term clinical case follow up^10,11

Unique and pioneer⁶

Approved in +90 countries⁷

JOIN US AT

AAP CORPORATE FORUM

Wednesday, October 15, 2025 | Room 601 AB

Dr. Arndt Guentsch

Clinical Strategies with Emdogain: Turning Biology into Better Outcomes

1:00 p.m. – 1:45 p.m.

Dr. Shayan Barootchi

The Modern Landscape of Implant Therapy: Immediacy, Soft Tissue Engineering, and Digital Innovations

2:05 p.m. – 2:50 p.m.

Dr. Phil Walton

Guided Implant Workflows for Full Arch: Practically Speakings

3:10 p.m. – 3:55 p.m.

Dr. Luis H. Gonzaga

Singles to Full Arch: The Latest Innovations in Straumann’s Digital Workflow Through a Prosthetic Lens

4:15 p.m. – 5:00 p.m.

Features and benefits

Peace of Mind

Straumann® Emdogain® is backed by extensive clinical documentation. Over the past 30 years it has been used in over 3 million patients³ and documented in over 1,700 scientific publications.²

Handling

As it is a gel, Straumann® Emdogain® is easy to apply, even when the defect is difficult to access.

Comfort

In a randomized clinical study Emdogain was compared to barrier membranes for treatment of mandibular buccal class II furcation defects. Both treatments led to significant clinical improvements. There was a significantly greater reduction in horizontal furcation depth with Emdogain. Patients treated with Emdogain also reported a lower incidence of postoperative pain and swelling at one week post op⁸.

Predictability

A prospective multicentre randomized controlled clinical trial was executed to compare the papilla preservation flap surgery with or without Emdogain for treatment of intrabony defects. After one year, on average clinical attachment level gain and pocket reduction was significantly higher with Emdogain⁹.

WEBINARS

Dr. David Lipton

30 years with Emdogain®: History, Biology and Clinical Applications

Tuesday, September 9th | 7:00 PM EDT (New York)

Dr. Arndt Guentsch

Clinical Strategies with Emdogain: Turning Biology into Better Outcomes

Wednesday, November 19th | 7:00 PM EDT (New York)

REGISTER FOR FREE

CUSTOMER INSIGHTS

coming soon

SUBMIT A CASE

In recognition of 30 years of this advancing and groundbreaking solution, we invite clinicians to submit their case studies and be part of our 30 year anniversary casebook. Celebrate the progress in regenerative dentistry—and shape its future. Your work could inspire the next generation of clinical innovation!

To view the full terms and conditions for case submission requirements, click here.
All submissions must include the Straumann Case Evaluation Form and the provided template.

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Last Name*

Email Address*

Practice Name*

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Important Safety information:

Indications for Use
Emdogain is intended as an adjunct to periodontal surgery as a topical application onto exposed root surfaces. Emdogain is indicated for the treatment of the following conditions:

Intrabony defects due to moderate or severe periodontitis
Mandibular degree II furcations with minimal interproximal bone loss
Gingival recession defects in conjunction with surgical coverage procedures such as the coronally advanced flap technique
Emdogain is also indicated for use in a minimally invasive surgical technique in esthetic zones to optimize tissue height for intrabony defects only.

In cases of wide defects or where soft tissue support is desired, Straumann® Emdogain can be used in conjunction with a bone graft material. For further information on the use of Emdogain with bone graft materials, please refer to “For Straumann® Emdogain in Conjunction with Bone Graft Material in Wide Defects” in the Clinical Procedure Section of the instructions.

Contraindications
Emdogain should not be used in patients with disorders or conditions including but not limited to the following: uncontrolled diabetes or other uncontrolled systemic diseases, disorders or treatments that compromise wound healing, chronic high dose steroid therapy, bone metabolic diseases, radiation or other immuno-oppressive therapy and infections or vascular impairment at the surgical site.

For complete labeling refer to ifu.straumann.com.

References

¹Bosshardt DD. Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels. J Clin Periodontol. 2008 Sep;35(8 Suppl):87-105.
² According to PUBMED search for “Emdogain” or “enamel matrix derivative”.
³ Based on the number of syringes sold to date globally.
⁴ Based on a global post-surgical complication rate of less than 0.003%.
⁵ Based on 2 indications: intrabony defects and recession coverage. (+10years clinical evidence).
⁶ Based on PI / unique patented formulation.
⁷ Regulatory approvals per country.
⁸ Jepsen S, Heinz B, Jepsen K, Arjomand M, Hoffmann T, Richter S, Reich E, Sculean A, Gonzales JR, Bödeker RH, Meyle J. A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal Class II furcation involvement in mandibular molars. Part I: Study design and results for primary outcomes. J Periodontol. 2004 Aug;75(8):1150-60.
⁹ Tonetti et al. Enamel matrix proteins in the regenerative therapy of deep intrabony defects – A multicenter, randomized, controlled clinical trial. J Clin Periodontology 2002;29;317-325.
¹⁰ McGuire MK, Scheyer ET, Nunn M. Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue: comparison of clinical parameters at 10 years. J Periodontol. 2012 Nov;83(11):1353-62.
¹¹ Sculean A, Kiss A, Miliauskaite A, Schwarz F, Arweiler NB, Hannig M. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. J Clin Periodontol 2008; doi: 10 .1111 /j .1600-051X .2008. 01295 .x.