SLActive® in irradiated patients.

Predictability beyond expectations

One of the most challenging patient groups for implant treatment includes patients who have undergone a combination of tumor surgery, chemotherapy and radiotherapy. The bone quality in these patients is severely compromised. 

SLActive® performance in irradiated patients

1-year follow-up3


1 patient was excluded from the study due to tumour recurrence. The graph is thus based on 19 patients with 97 implants.

5-year follow-up13,14


Excluding 4 further patients deceased due to cancer The graph is thus based on 15 patients with 79 implants.

Randomized clinical trial:3
102 implants, 20 patients
Post-surgery, radiotherapy and chemotherapy for oral carcinoma

What clinicians say

News update from Dental Tribune International

Watch an interview with Prof Nelson to get to know more about the study and challenges of prosthetic rehabilitation of irradiated patients. Discover how SLActive® implants improved the quality of life in these patients.

Uncompromised performance.

Even in diabetic patients.

  • Patients with diabetes have reduced wound healing capacity15,16 which puts implants at risk. Learn more >

  • Worldwide, 1 in 6 adults 60 years of age and older  has diabetes.17 Learn more >

Given the ever rising prevalence of type 2 diabetes, how can clinicians address this risk particularly in older patients?

  • Growing clinical evidence of highly predictable performance of slactive® in diabetic patients. 
  • A new clinical study19 that compared SLActive® performance in patients with and without dia­betes showed uncompromised performance of SLActive® implants.
  • 100 % implant success rate in the diabetic group after 2 years
  • Bone changes similar to those in healthy individuals
  • Despite the observed lower levels of bone quality all implants in this study showed good primary stability.

Performance in diabetic patient group19

Prospective case-control clinical study (15 diabetic and 14 non-diabetic individuals)


  • 100% implant success rate in the diabetic group after 2 years

  • Bone changes similar to those in healthy individuals

  • Despite the observed lower levels of bone quality all implants in this study showed good primary stability.

Key researchers behind the study

What clinicians say

The placement of implants in smokers is often associated with high failure rates, risk of post-operative infections, and marginal bone loss.29

SLActive® – high predictability in smokers​

  • A recent clinical study comparing SLActive® performance in smokers and non-smoker patient groups reported excellent outcomes with SLActive®:​
  • 96 patients, 130 SLActive® implants, 5-year follow-up, 100% survival rate

Performance in smoker patient group30

Prospective case-control clinical study (47 smokers and 49 non-smokers)


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References

* Success criteria as per Buser D. et al. Long-term stability of osseointegrated implants in augmented bone: A 5-year prospective study in partially edentulous patients. Int J Periodont Restor Dent. 2002; 22: 108–17.
** Adjusted, excluding the patients deceased due to cancer mortality.

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4 Yerit, K., Posch, M., Seemann, M., Hainich, S., Dortbudak, O., Turhani, D., Ozyuvaci, H., Watzinger, R. and Ewers, R. (2006) Implant Survival in Mandibles of Irradiated Oral Cancer Patients. Clinical Oral Implants Research, 17, 337-344. http://dx.doi.org/10.1111/j.1600-0501.2005.01160.x.
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14 C. NACK, J.-D. RAGUSE, A. STRICKER , K. NELSON & S. NAHLES. Rehabilitation of irradiated patients with chemically modified and conventional SLA implants: five-year follow-up. Journal of Oral Rehabilitation 2015 42; 57—64.
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16 Wang F1, Song YL, Li DH, Li CX, Wang Y, Zhang N, Wang BG. Type 2 diabetes mellitus impairs bone healing of dental implants in GK rats. Diabetes Res Clin Pract. 2010; 88:e7-9.
17 IDF Diabetes Atlas, 7th Edition, 2015 http://www.diabetesatlas.org/.
18 US Centers for Disease Control and Prevention. Diabetes 2014 report card. Available from: www.cdc.gov/diabetes/library/reports/congress.html. Accessed September 2015.
19 Cabrera-Domínguez J, Castellanos-Cosano L, Torres-Lagares D, Machuca-Portillo G. A Prospective Case-Control Clinical Study of Titanium-Zirconium Alloy Implants with a Hydrophilic Surface in Patients with Type 2 Diabetes Mellitus. Int J Oral Maxillofac Implants. 2017 Sep/Oct;32(5):1135-1144. doi: 10.11607/jomi.5577; Cabrera-Domínguez J. A prospective, two-year clinical trial of titanium-zirconium alloy implants (Roxolid® Straumann®) with hydrophilic surface (SLActive®) in patients with Type 2 Diabetes Mellitus. presented during 26th Annual Scientific Meeting of the European Association of Osseointegration – 5-7 Oct 2017, Madrid, Spain.
20 Hotchkiss KM, Ayad NB, Hyzy SL, Boyan BD, Olivares-Navarrete R. Dental implant surface chemistry and energy alter macrophage activation in vitro. Clin. Oral Impl. Res. 00, 2016, 1–10. doi: 10.1111/clr.12814.
21 Lee R, Hamlet SM, Ivanovski S. The influence of titanium surface characteristics on macrophage phenotype polarization during osseous healing in type I diabetic rats: A pilot study. Clin Oral Impl Res (accepted 4/8/2016).
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25Stavropoulos A et al. Greater Osseointegration Potential with Nanostructured Surfaces on TiZr: Accelerated vs. Real-Time Ageing. Materials (Basel). 2021 Mar 29;14(7):1678.
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28 Wennerberg A, Jimbo R, Stübinger S, Obrecht M, Dard M, Berner S. Nanostructures and hydrophilicity influence osseointegration – A biomechanical study in the rabbit tibia. Clin. Oral Impl. Res. 25, 2014, 1041–1050doi: 10.1111/clr.12213
29 Chrcanovic BR, Albrektsson T, Wennerberg A Smoking and dental implants: A systematic review and meta-analysis. J Dent. 2015 May;43(5):487-98
30 Alsahhap A et al. Survival of Titanium-Zirconium and Titanium Dental Implants in Cigarette-smokers and Never-smokers: A 5-Year Follow-up. Chin J Dent Res. 2019;22(4):265-272
31 Hotchkiss KM et al. Novel in vitro comparative model of osteogenic and inflammatory cell response to dental implants. Dent Mater. 2019 Jan;35(1):176-184.
32 Hsu JT, Shen YW, Kuo CW, Wang RT, Fuh LJ, Huang HL. Impacts of 3D bone-to- implant contact and implant diameter on primary stability of dental implant. J Formos Med Assoc. 2017 Aug;116(8):582-590. ; Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res. 1991 Jul;25(7):889-902 ; Smeets R, Stadlinger B, Schwarz F, Beck-Broichsitter B, Jung O, Precht C, Kloss F, Gröbe A, Heiland M, Ebker T. Impact of Dental Implant Surface Modifications on Osseointegration. Biomed Res Int. 2016;2016:6285620. ; Goyal N., Priyanka R. K. Effect of various implant surface treatments on osseointegration – a literature review. Indian Journal of Dental Sciences. 2012;4:154–157