Digest
A 30-year evolution of periodontal regeneration
Professor Anton Sculean opens this session 3 with a historical and scientific overview of Emdogain®, an enamel matrix derivative (EMD) used for periodontal regeneration and more. He emphasizes that Emdogain® isn't a new product but one with a rich legacy backed by over 1000 PubMed studies. These studies identify a cocktail of enamel-derived proteins essential for cementogenesis and periodontal ligament regeneration. Pioneered by researchers Lars Hammarström et al., these proteins interact with stem cells and growth factors such as TGF-beta, PDGF, and BMPs to facilitate healing at both the cellular and tissue levels. Sculean illustrates the material’s long-term efficacy through case studies, including vertical and horizontal bone defect healing with follow-ups of up to 10 years.
Technique refinement and clinical application
Following Sculean, Dr. Serhat Aslan introduces a biologically focused, microsurgical approach to flap design that enhances the effectiveness of Emdogain®. He highlights papillary preservation techniques as key to achieving predictable regenerative outcomes, stressing the role of vascularization and tissue compatibility. Dr. Aslan provides detailed step-by-step instructions on using PrefGel® (EDTA), applying Emdogain under controlled thermal conditions, and executing minimally invasive suturing techniques. He further discusses the biomechanical and anatomical considerations of periodontal defects, showcasing how the strategic use of Emdogain with connective tissue grafts and precise flap manipulation can result in significant aesthetic and functional improvement, even in severe cases.
Protocol-based periodontal excellence
Dr. Meizi Eliezer concludes the session by showcasing her structured clinical protocol, emphasizing the integration of Emdogain® and Emdogain® FL across a wide range of periodontal defects—from recession coverage to flapless applications in systemic-compromised patients. She shares a compelling series of clinical cases, highlighting regenerative success in diabetic patients, post-orthodontic recessions, and severe infrabony defects. Dr. Eliezer emphasizes the importance of proper diagnosis, oral hygiene education, and initial therapy before employing regenerative techniques. She stresses that the long-term stability of results—documented in some cases over five years—depends on biologically driven treatment planning, appropriate material selection, and patient compliance.
Key takeaways
- Emdogain® remains the most documented and effective biologic for periodontal regeneration
- Biological understanding and technique precision are critical for clinical success
- Systematic protocols and patient-centered care enhance long-term regenerative outcomes
