STUDY OBJECTIVES AND METHODS
The purpose of this study was to evaluate the effect of enamel matrix derivative (EMD) and porcine collagen matrix, alone orcombined, on wounds made on the rat dorsum. Wounds were created in the dorsum of 40 Wistar rats divided into 4 samgroups: G1 = clot, G2 = porcine collagen matri x (Straumann® Mucoderm®), G3 = enamel matrix derivative (EMD, Emdogain®), G4= porcine collagen matrix (Straumann® Mucoderm®) and EMD (Emdogain®). The animals were euthanized on days 7 andtheir wound was evaluated histologically to assess wound cl osure and re-epithelialization, and to measure tissue inflammation.
RESULTS
- At 7 days, groups treated with EMD (G3 and G4) exhibited significantly lower inflammation scores compared to GG2 (p < 0.05).
- At 14 days, all groups showed complete wound closure with no significant differences in inflammatory scores. HoG3 demonstrated a markedly greater epithelial thickness, with epithelial projections into the underlying connecttissue and evidence of keratin formation.
- Collagen fiber organization was also more evident in G3 and G4
CONCLUSIONS
Theporcine collagen matrix, whether alone or combined, promoted tissue regeneration, and the combination of these substitutes with EMD, resulted in less tissue inflammation and greater epithelial thickness. These advantages emphasizeuse for soft tissueaugmentation and improvement. Adapted from Julius Cezar Coelho Moraes et al., Int J Implant Dent. 2025 Oct 22;11(1):66 , for more info about this publication, click HERE.
This review is part of the Straumann "Scientific Highlights Newsletter 6/25".
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- Health of peri-implant soft tissues adjacent to glazed or polished monolithic zirconia: a randomized clinical trial
- Evaluation of enamel matrix derivative used alone or added to collagen membrane tissue repair: in vivo animal study using a rat dorsal wound model
- Peri-Implant Supracrestal Tissue Characteristics Related to Abutment Materials: A Comparative Histomorphometry Study
- Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical
