maxresorb®
Biphasic calcium phosphate granules.

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Based on the knowledge on synthetic biphasic calcium phosphates, maxresorb® comes with a nanostructured surface to provide ideal conditions for the adhesion of osteoblasts. The slow resorption properties facilitate true bone regeneration. 1-5

Features and benefits

Reproducibility and safety

The chemical process technology used in the production of maxresorb® ensures high reproducibility and safety of the material. The chemical process technology used in the production of maxresorb® ensures high reproducibility and safety of the 100% synthetic material. 6
Biofunctionality

maxresorb® exhibits a controlled biphasic resorption; initial integration of the particles followed by complete resorption. While the fast resorption of β-TCP quickly offers space for new bone formation, the HA component provides volume stability for an extended time period. 1,2
Homogenous composition

maxresorb® is not only a mixture of HA and β-TCP particles. During the production process HA and β-TCP are brought together in a ceramic slurry, which is then foamed and freeze-dried to form particles containing both phases. The fast resorption of the β-TCP component continuously increases the porosity of the material promoting tissue integration by allowing ingrowth of cells and blood vessels. 7,8
Surface roughness

The prominent surface roughness of maxresorb® facilitates adhesion of cells and proteins and offers excellent hydrophilicity. maxresorb® is therefore a prominent scaffold for the migration of bone forming cells and binding of signaling molecules from the blood, which lead to accelerated integration and tissue regeneration. 5,9,10
Excellent handling

maxresorb® mixes well with autogenous bone, blood or saline solution. It retains liquids facilitating quick and extensive wetting of particles with blood or saline solution. The stickiness of wetted particles allows for quick and easy application to the defect site.

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References

1.Daculsi 1998. Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute. Biomaterials 19(16):1473–1478.
2.Ducheyne et al. 1993. The effect of calcium phosphate ceramic composition and structure on in vitro behavior. I. Dissolution. Journal of biomedical materials research. 27(1):25–34.
3.Mate Sanchez et al. 2016. Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reaction in vivo. Part B: a comparative study with biphasic synthetic biomaterials. Clin Orla Implants Res. 29(11):1077-1084.
4.Calvo-Guirado et al. 2012. Histomorphometric and mineral degradation study of Ossceram: a novel biphasic B-tricalcium phosphate, in critical size defects in rabbits. Clin Oral Implants Res. 23(6):667-675.
5.Rothamel et al. 2009. Wissenschaftlich-experimentelle Untersuchung des biphasischen Knochenersatzmaterials Ossceram nano: Oberflachenstruktur, Biokompatibilitat und Hartgewebsregeneration. Z Oral Implant 5/2009.
6.Jelušić et al. Monphasic β-TCP vs. biphasic HA/β-TCP in two.stage sinus floor augmentation procedures - a prospective randomized cliical trial. Clin Oral Impl Res. 00, 2016, 1-9 [Epub ahead of print]
7.Gauthier et al. 1999. Elaboration conditions influence physicochemical properties and in vivo bioactivity of macroporous biphasic calcium phosphate ceramics. Journal of materials science. Materials in medicine 10(4):199–204.
8. Schwartz et al. 1999. Biphasic synthetic bone substitute use in orthopaedic and trauma surgery: clinical, radiological and histological results. Journal of materials science. Materials in medicine 10(12):821–825.
9.Fujioka-Kobayashi et al. 2016. Recombinant human bone morphogenetic protein (rhBMP)9 induces osteoblast differentiation when combined with demineralized freeze-dried bone allografts (DFDBAs) or biphasic calcium phosphate (BCP). Clin Oral Investig. 21(5):1883-1893.
10. Trajkovski et al. 2018. Hydrophilicity, Viscoelastic, and Physicochemical Properties Variations in Dental Bone Grafting Substitutes. Materials (Basel). 11(2):215.