5 McGuire MK, et al.A Prospective, Cased-Controlled Study Evaluating the use of Enamel Matrix Derivative on Human Buccal Recession Defects: A Human Histologic Examination.J Periodontol.2016 Feb 1:1-34.
6 Sculean A, et al.Clinical and histologic evaluation of
human intrabony defects treated with an enamel matrix protein derivative (Emdogain).Int J Periodontics Restorative Dent.2000;20:374–381.
7 Aspriello SD, et al.Effects of enamel matrix derivative on vascular endothelial growth factor expression and microvessel density in
gingival tissues of periodontal pocket: a comparative study.J Periodontol.2011 Apr;82(4):606-12.
8 Guimarães et al.Microvessel Density
Evaluation of the Effect of Enamel Matrix Derivative on Soft Tissue After Implant Placement: A Preliminary Study.Int J Periodontics Restorative
Dent.2015 Sep-Oct;35(5):733-8.
9 Sato et al.Enamel matrix derivative exhibits anti-inflammatory properties in monocytes J Periodontol.
Mar 2008;79(3):535-40
10 Arweiler et al.Antibacterial effect of an enamel matrix protein derivative on in vivo dental biofilm vitality.Clin Oral Investig.2002 Dec;6(4):205‑9.Epub 2002 Nov 14.
11 Maymon-Gil T, et al.Emdogain Promotes Healing of a Surgical Wound in the Rat Oral Mucosa.J. Periodontol.2016 Jan 16:1-16.
12 Tonetti et al.Enamel matrix proteins in the regenerative therapy of deep intrabony defects – A multicenter,
randomized, controlled clinical trial.J Clin Periodontology 2002;29;317-325
13 Tonetti MS et al.Clinical efficacy of periodontal plastic surgery
procedures: consensus report of Group 2 of the 10th European Workshop on Periodontology.J Clin Periodontol.2014 Apr;41 Suppl 15:S36-43
14 McGuire MK, et al.Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or
connective tissue: comparison of clinical parameters at 10 years.J Periodontol.2012 Nov;83(11):1353-62
15 Villa O et al.J Periodontol.A Proline-Rich Peptide Mimic Effects of EMD in Rat Oral Mucosal Incisional Wound Healing.2015 Dec;86(12):1386-95.
16 Jepsen S, et al.A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal Class II furcation involvement in mandibular molars.Part I: Study design and results for primary outcomes. J Periodontol.2004 Aug;75(8):1150-60.
17 According to PUBMED - search term “Emdogain" or "enamel matrix derivative”.
18 Sculean A, et al.Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue
regeneration.J Clin Periodontol.2008 Sep;35(9):817-24
19「Emdogain」または「エナメルマトリックス派生物」に関するPUBMED検索に基づく
20現在までに全世界で販売されたシリンジの数に基づく。
21全世界で術後合併症の発生率は0.003%未満であることに基づく。
22 骨縁下欠損と退縮を対象とする2つの適応に基づく。(10年以上の臨床エビデンス)
23 PI/独自の特許取得済み配合に基づく
24 国ごとの規制承認
